Epitalon — Annual Longevity Cycle
The signature pineal-peptide cycle: a short course of epitalon run once or twice a year, mirroring the pulsed schedule from the original Khavinson human work.
Why this protocol
epitalon is a four-amino-acid peptide associated with the pineal gland and studied — primarily by Khavinson and colleagues — for effects on melatonin rhythm and, in some reports, telomerase activity. Unlike a daily peptide, it is run as a short pulsed course and then put away for months, which is exactly how the original human studies dosed it.
It is a mono protocol by design: the evidence and the convention are both built around a single agent on a periodic course, not a stack. An evening injection is the community preference, reasoning from its proposed pineal/melatonin mechanism.
Community / practitioner convention drawn from the cited Khavinson human work — framed honestly as a pulsed course, not a trial-validated annual prescription. Doses match the epitalon page; the telomerase rationale remains a hypothesis, not a proven mechanism.
The regimen
Epitalon
Pineal cycle- Dose
- 0.5–1 mg per injection (5–10 mg per course)
- Schedule
- 10–20 consecutive daily injections · subcutaneous
- Timing
- Evening
Reconstitution calculator
Reconstitution calculator
Calculated for a 1 mL U-100 insulin syringe (100 units/mL).
Units per dose
20
Draw to this mark on a U-100 syringe
- Volume per dose
- 0.2 mL
- Doses per vial
- 10
- Concentration
- 5 mg/mL
One vial lasts
- Daily
- 10 days
- Every other day
- 20 days
- 5×/week
- 14 days
Research use only. Not for human consumption. Outputs are reference values based on research literature — verify all measurements independently.
Cycle & schedule
Course (10–20 days)
Epitalon 0.5–1 mg once daily in the evening for 10–20 consecutive days, totalling 5–10 mg — the pattern from the original Khavinson injectable-epithalamin work.
Off-period (several months)
Then a gap of several months before repeating. The Khavinson cohorts repeated courses periodically across years rather than dosing continuously.
Studies behind this protocol
This protocol composes the cited evidence on each peptide's page — see the full bibliography on: Epitalon.
Research use only · Not medical advice · Updated 2026-06-01