Epitalon's annual longevity cycle
Epitalon is the signature pineal-peptide cycle. People run a short course once or twice a year, mirroring the pulsed schedule from the original Khavinson human work.
10–20 day course · repeated every several months
Why this protocol
Epitalon is a four-amino-acid peptide associated with the pineal gland, studied primarily by Khavinson and colleagues for effects on melatonin rhythm and, in some reports, telomerase activity. Unlike a daily peptide, it is run as a short pulsed course and then put away for months, which is exactly how the original human studies dosed it.
It is a mono protocol by design. The evidence and the convention are both built around a single agent on a periodic course, not a stack. An evening injection is the community preference, reasoning from its proposed pineal/melatonin mechanism.
The regimen
Epitalon
Pineal cycle- Dose
- 0.5–1 mg per injection (5–10 mg per course)
- Schedule
- 10–20 consecutive daily injections · subcutaneous
- Timing
- Evening
Reconstitution calculator
Reconstitution calculator
Calculated for a 1 mL U-100 insulin syringe (100 units/mL).
Units per dose
100 units
Draw this many units on a U-100 syringe
Each unit holds 50 mcg
- Volume per dose
- 1 mL
- Doses per vial
- 2
- Concentration
- 5 mg/mL
One vial lasts
- Daily
- 2 days
- Every other day
- 4 days
- 5×/week
- 2 days
- Large draw (100 units). That's normal for mg doses. To check it, multiply the units by what each unit holds. You should get your dose.
Research use only. Not for human consumption. Outputs are reference values based on research literature. Verify all measurements independently.
Cycle & schedule
- Course (10–20 days)Epitalon 0.5–1 mg once daily in the evening for 10–20 consecutive days, totalling 5–10 mg. That's the pattern from the original Khavinson injectable-epithalamin work.
- Off-period (several months)Then a gap of several months before repeating. The Khavinson cohorts repeated courses periodically across years rather than dosing continuously.
Studies behind this protocol
This protocol composes the cited evidence on each peptide's page. See the full bibliography on: Epitalon.
Research use only · Not medical advice · Updated 2026-09-24