5-Amino-1MQ — Metabolic Support
5-amino-1mq blocks the NNMT enzyme to ease a metabolic brake on fat cells and cellular energy — a once-daily metabolic protocol, run in blocks.
Why this protocol
5-amino-1mq is a small-molecule inhibitor of NNMT (nicotinamide N-methyltransferase), an enzyme that, when overactive in fat tissue, acts as a metabolic brake. By inhibiting it, the compound is studied for freeing up cellular energy metabolism and supporting fat loss — most relevant alongside diet and training.
It is run as a mono protocol on a once-daily schedule. Because it is reached for during a fat-loss or recomposition phase, it is typically paired with a calorie-controlled, higher-protein diet rather than another peptide on the same lever.
Convention drawn from the 5-Amino-1MQ page's cited evidence — the human data are early, so the dose and once-daily schedule are practitioner/community convention extrapolated from mechanism, not a trial-proven regimen. No therapeutic claims; metabolic support is an adjunct to diet and training.
The regimen
5-Amino-1MQ
NNMT inhibition- Dose
- 50 mg
- Schedule
- Once daily · subcutaneous
- Timing
- Fasted (e.g. morning, before food)
Reconstitution calculator
Reconstitution calculator
Calculated for a 1 mL U-100 insulin syringe (100 units/mL).
Units per dose
20
Draw to this mark on a U-100 syringe
- Volume per dose
- 0.2 mL
- Doses per vial
- 10
- Concentration
- 25 mg/mL
One vial lasts
- Daily
- 10 days
- Every other day
- 20 days
- 5×/week
- 14 days
Research use only. Not for human consumption. Outputs are reference values based on research literature — verify all measurements independently.
Cycle & schedule
Daily block
5-Amino-1MQ 50 mg once daily, fasted, alongside a calorie-controlled, higher-protein diet and training for the goal it supports.
Washout (≥4 weeks)
Take at least a 4-week break before re-running a block, letting methylation flux normalize.
Studies behind this protocol
This protocol composes the cited evidence on each peptide's page — see the full bibliography on: 5-Amino-1MQ.
Research use only · Not medical advice · Updated 2026-06-01