5-Amino-1MQ for metabolic support
5-Amino-1MQ blocks NNMT, an enzyme that uses up an NAD+ building block. People run 5 mg under the skin each morning, in blocks with breaks.
Daily blocks + 4-week washout
Why this protocol
5-Amino-1MQ is a small-molecule inhibitor of NNMT (nicotinamide N-methyltransferase). NNMT runs high in obese fat tissue. Blocking it in fat cells spares NAD+ and SAM, the cell's main methyl donor, and cuts fat storage.
People run it on its own, once a day, during a fat-loss or recomposition phase. Most pair it with a calorie-controlled, higher-protein diet and training for the goal.
The regimen
5-Amino-1MQ
NNMT inhibition- Dose
- 5 mg
- Schedule
- Once daily · subcutaneous
- Timing
- Morning
Reconstitution calculator
Reconstitution calculator
Calculated for a 1 mL U-100 insulin syringe (100 units/mL).
Units per dose
20 units
Draw this many units on a U-100 syringe
Each unit holds 250 mcg
- Volume per dose
- 0.2 mL
- Doses per vial
- 10
- Concentration
- 25 mg/mL
One vial lasts
- Daily
- 10 days
- Every other day
- 20 days
- 5×/week
- 14 days
Research use only. Not for human consumption. Outputs are reference values based on research literature. Verify all measurements independently.
Cycle & schedule
- Daily blockPeople run 5-Amino-1MQ at 5 mg once a day in the morning, alongside a calorie-controlled, higher-protein diet and training.
- Washout (≥4 weeks)At least 4 weeks off before the next block.
Studies behind this protocol
This protocol composes the cited evidence on each peptide's page. See the full bibliography on: 5-Amino-1MQ.
Research use only · Not medical advice · Updated 2026-10-04