Retatrutide + 5-Amino-1MQ for body composition
Retatrutide cuts appetite. 5-Amino-1MQ blocks NNMT inside fat cells. People run the two together for recomposition.
Retatrutide weekly titration + 5-Amino-1MQ daily
Why this protocol
Retatrutide acts on three hormone receptors, GLP-1, GIP and glucagon. It cuts appetite and improves glucose control. In obese mice it also raised energy use. 5-Amino-1MQ works a different way. It blocks NNMT inside fat cells, which spares NAD+ and cuts fat storage.
One compound targets appetite, the other fat-cell metabolism. It is an advanced stack. People bring retatrutide up slowly on its own schedule and add 5-Amino-1MQ once that is tolerated.
The regimen
Retatrutide
Appetite / triple agonist- Dose
- Start 2 mg/week → 4 / 9 / 12 mg/week
- Schedule
- Once weekly · subcutaneous
- Timing
- One consistent day each week; step up by gut tolerance
Reconstitution calculator
Reconstitution calculator
Calculated for a 1 mL U-100 insulin syringe (100 units/mL).
Units per dose
40 units
Draw this many units on a U-100 syringe
Each unit holds 100 mcg
- Volume per dose
- 0.4 mL
- Doses per vial
- 5
- Concentration
- 10 mg/mL
One vial lasts
- Daily
- 5 days
- Every other day
- 10 days
- 5×/week
- 7 days
- Large draw (40 units). That's normal for mg doses. To check it, multiply the units by what each unit holds. You should get your dose.
Research use only. Not for human consumption. Outputs are reference values based on research literature. Verify all measurements independently.
5-Amino-1MQ
Fat-cell metabolism (NNMT)- Dose
- 5 mg
- Schedule
- Once daily · subcutaneous
- Timing
- Morning
Reconstitution calculator
Reconstitution calculator
Calculated for a 1 mL U-100 insulin syringe (100 units/mL).
Units per dose
20 units
Draw this many units on a U-100 syringe
Each unit holds 250 mcg
- Volume per dose
- 0.2 mL
- Doses per vial
- 10
- Concentration
- 25 mg/mL
One vial lasts
- Daily
- 10 days
- Every other day
- 20 days
- 5×/week
- 14 days
Research use only. Not for human consumption. Outputs are reference values based on research literature. Verify all measurements independently.
Cycle & schedule
- Establish Retatrutide (titration)People start retatrutide low, once a week, and step up by gut tolerance toward their target, on the schedule from the Retatrutide page. They hold a tolerated dose before adding anything else.
- Layer in 5-Amino-1MQOnce retatrutide is tolerated, 5-Amino-1MQ goes in at 5 mg once a day in the morning, alongside a calorie-controlled, higher-protein diet and training.
- 5-Amino-1MQ washout5-Amino-1MQ runs in blocks with at least 4 weeks off between them. Retatrutide stays on its own schedule.
Studies behind this protocol
This protocol composes the cited evidence on each peptide's page. See the full bibliography on: Retatrutide, 5-Amino-1MQ.
Research use only · Not medical advice · Updated 2026-10-04