GLP3-RT + 5-Amino-1MQ — Body Composition
glp3-rt curbs appetite and drives weight loss while 5-amino-1mq eases a metabolic brake on fat cells — appetite plus fat-cell metabolism, two different levers for recomposition.
Why this protocol
glp3-rt is a GLP-1/GIP/glucagon triple agonist: it reduces appetite, improves insulin signaling, and raises energy expenditure — the dominant driver of weight loss. 5-amino-1mq works on a different lever, inhibiting NNMT inside fat cells to support fat metabolism.
Appetite/satiety from one side and fat-cell metabolism from the other is a genuinely complementary pairing for body recomposition. It is an advanced stack: GLP3-RT must be titrated slowly on its own ladder, and 5-Amino-1MQ is layered in once that is tolerated.
GLP3-RT is an investigational compound and this combination is body-composition convention, not a studied regimen — doses match each peptide's page, and weight figures are GLP3-RT trial findings, not a promise. Advanced: titrate GLP3-RT carefully. No therapeutic claims.
The regimen
GLP3-RT
Appetite / triple agonist- Dose
- Start 1 mg/week → 4 / 8 / 12 mg/week
- Schedule
- Once weekly · subcutaneous
- Timing
- One consistent day each week; titrate by GI tolerance
Reconstitution calculator
Reconstitution calculator
Calculated for a 1 mL U-100 insulin syringe (100 units/mL).
Units per dose
80
Draw to this mark on a U-100 syringe
- Volume per dose
- 0.8 mL
- Doses per vial
- 2
- Concentration
- 5 mg/mL
One vial lasts
- Daily
- 2 days
- Every other day
- 5 days
- 5×/week
- 3 days
- Large draw (80 units). Double-check the vial size and dose — a mcg/mg mix-up produces values like this.
Research use only. Not for human consumption. Outputs are reference values based on research literature — verify all measurements independently.
5-Amino-1MQ
Fat-cell metabolism (NNMT)- Dose
- 50 mg
- Schedule
- Once daily · subcutaneous
- Timing
- Fasted (e.g. morning)
Reconstitution calculator
Reconstitution calculator
Calculated for a 1 mL U-100 insulin syringe (100 units/mL).
Units per dose
20
Draw to this mark on a U-100 syringe
- Volume per dose
- 0.2 mL
- Doses per vial
- 10
- Concentration
- 25 mg/mL
One vial lasts
- Daily
- 10 days
- Every other day
- 20 days
- 5×/week
- 14 days
Research use only. Not for human consumption. Outputs are reference values based on research literature — verify all measurements independently.
Cycle & schedule
Establish GLP3-RT (titration)
Start GLP3-RT at 1 mg once weekly and step up by GI tolerance toward a 4/8/12 mg target. Get this stable before adding anything.
Layer in 5-Amino-1MQ
Once GLP3-RT is tolerated, add 5-Amino-1MQ 50 mg once daily (fasted), alongside a calorie-controlled, higher-protein diet and training.
5-Amino-1MQ washout
Run 5-Amino-1MQ in blocks with at least a 4-week break between blocks; manage GLP3-RT on its own long taper.
Studies behind this protocol
This protocol composes the cited evidence on each peptide's page — see the full bibliography on: GLP3-RT, 5-Amino-1MQ.
Research use only · Not medical advice · Updated 2026-06-01